Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 57 0.0 0.559 0.054 0.113
biological_process el 57 0.09 0.971 0.687 0.27
biological_process ka 57 0.0 0.591 0.05 0.11
biological_process rf 57 0.0 0.559 0.054 0.113
cellular_component ct 57 0.0 0.558 0.077 0.131
cellular_component el 57 0.007 0.967 0.375 0.273
cellular_component ka 57 0.0 0.547 0.078 0.132
cellular_component rf 57 0.0 0.558 0.077 0.131
disease ct 16 0.002 0.945 0.236 0.313
disease el 16 0.013 0.827 0.5 0.249
disease ka 16 0.0 0.622 0.2 0.245
disease rf 16 0.002 0.934 0.235 0.311
genetic_interaction ct 51 0.0 0.991 0.396 0.326
genetic_interaction el 51 0.0 0.972 0.403 0.326
genetic_interaction ka 51 0.0 0.026 0.005 0.006
genetic_interaction rf 51 0.0 0.978 0.391 0.323
molecular_function ct 57 0.0 0.832 0.081 0.179
molecular_function el 57 0.047 0.991 0.463 0.223
molecular_function ka 57 0.0 0.817 0.072 0.161
molecular_function rf 57 0.0 0.832 0.078 0.176
pathway ct 27 0.0 0.996 0.066 0.188
pathway el 27 0.0 0.185 0.027 0.048
pathway ka 27 0.0 0.127 0.016 0.028
pathway rf 27 0.0 0.157 0.027 0.043
phenotype ct 17 0.0 0.936 0.263 0.308
phenotype el 17 0.016 0.88 0.556 0.252
phenotype ka 17 0.0 0.992 0.293 0.342
phenotype rf 17 0.0 0.929 0.263 0.307
protein_interaction ct 59 0.0 0.349 0.021 0.062
protein_interaction el 59 0.0 0.39 0.018 0.057
protein_interaction ka 59 0.0 0.032 0.002 0.005
protein_interaction rf 59 0.0 0.325 0.02 0.06

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 59 0.0 0.775 0.073 0.163
integration_mean_by_presence el 59 0.0 0.759 0.128 0.179
integration_mean_by_presence ka 59 0.0 0.733 0.052 0.148
integration_mean_by_presence rf 59 0.0 0.329 0.022 0.055
mean ct 59 0.0 0.724 0.05 0.133
mean el 59 0.0 0.5 0.068 0.119
mean ka 59 0.0 0.469 0.037 0.094
mean rf 59 0.0 0.328 0.027 0.067

CDF plots of non integrated kernels

CDF plots of integrated kernels